The very name of the city of Ciudad Bolivar refers to its protagonist, the liberator of the republic, and the people's favorite Simon Bolivar. Moreover, most of the city attractions are associated with his name. Streets, squares, parks, and the most significant place for the city and the republic - The House-Museum of San Isidro.

The building was constructed in the XVIII century in the Venezuelan city of Ciudad Bolivar. It was once one of the five most beautiful colonial-style buildings. Originally the building belonged to the Spanish don José Luis Cornieles and was part of his huge estate with coffee plantations. Then it was rented by the English printer Andres Roderick, who sailed to Venezuela in 1817 and established a small printing house there. There, on his typewriter, the liberator of the nation, Simon Bolivar, wrote his famous speech "Message to the Congress of Angostura, 1819". Later he pronounced it at the opening of the Congress of Angostura, as the city of Ciudad Bolivar was called at that time. As a result of this speech, several laws were adopted and the new Republic of Colombia was formed, which included the territories of modern Colombia, Venezuela, Ecuador, and Panama. Today, this speech continues to inspire many members of the legislature.

Over the years, the house has often changed its owners. It belonged to the diocese of Guayana and was supposed to be an orphanage. However, the government of the state bought the building and created a museum within the house in honor of the bishop of the diocese, Mariano Talavera y Garcés.

Today, it houses the Museum of San Isidro, founded in 1962. Its collections consist of household items from the time of Great Colombia, which included Venezuela, and works of art by masters of Latin America. The museum is surrounded by a beautiful garden with tamarind and bamboo trees. According to locals, the national hero of Venezuela, Simon Bolivar, tied his white horse to one of these trees.