The Museum of Guyanese Cultures (Musée des cultures guyanaises) is housed in a completely restored old creole house in the center of Cayenne. Founded in 1995, it became a community agency in 1998. Today, it welcomes everyone who wants to learn more about the Guyanese lifestyle.

The museum has a large collection of items that reflect traditional local life and demonstrate the cultural diversity of this French Department.

There are ethnographic items from the ethnic groups of French Guiana such as native Indians, the Maroons, the Creoles, the Hmong, Brazilians, and Haitians. The museum also has a collection of Indian and colonial archaeological objects, historical iconographic documents and documentary sound archives.

The museum staff collects, curates, and studies regional cultural objects created by ethnic groups and traditional societies of French Guiana. Special attention is paid to the evidence of knowledge and techniques of the traditional life of the past, which may be ousted or even disappear in modern realities.

The museum has two locations on Madame Payée Street. Temporary exhibitions are in house No. 78. It is a documentation center specializing in cultures, ethnic groups, and traditional societies of the region. At No. 54, you can see the reconstruction of an old сreole house that belonged to Herménégilde Tell, father-in-law of Félix Éboué', the first French black high-ranking colonial administrator and hero of the Resistance movement in the 1940s. This building also displays the everyday life of the local population. You can visit various exhibitions, study thematic materials and publications.

The institution participates in the regional scientific and cultural program, which aims to unite local museum items in a single system: the Museum of Guyanese Cultures, the Musée départemental Alexandre Franconie, and the archives départementales. The new cultural and exhibition center is planned to be located in the city center, in the former Jean Martial hospital.