Bicentennial Cultural Center of Santiago del Estero is located in the heart of the city, in the building of the province’s Government House. The complex has collections of three main city museums. These are Dr. Orestes Di Lullo Historical Museum, Emilio and Duncan Wagner Museum of Anthropology and Natural Sciences, and Ramón Gómez Cornet Museum of Fine Arts. The grand opening took place in 2010 with the participation of the provincial governor Gerardo Zamora and Argentine President Cristina Fernández de Kirchner.

The historic building was the property of the government, precisely - the headquarters of the police. It was built in 1868 by two Swiss architects, brothers Agustín and Nicolás Cánepa. The impressive size of the complex in the French neoclassical style confused the locals. They were calling it the town hall, though the city authorities have never worked there. From its founding to the 20th century, members of the Santiago del Estero government were sitting in this place.

In 1987, the building was considered a historical monument. After reconstruction, it became a cultural center. Its purpose was to preserve and protect historical and cultural heritage, as well as show it to the public.

Today, the cultural center of Santiago del Estero is very important in Northern Argentina. Museum collections present all the stages of human development. The Emilio and Duncan Wagner Museum of Anthropology and Natural Sciences has more than 3,000 exhibits. Among them are pots, funeral urns, arrowheads, and stone axes. Most of the collection was donated by Argentine archaeologist Dr. Alejandro Gancedo.

A collection of the Dr. Orestes Di Lullo History Museum tells the history of the province from ancient times to the present. You can see worship items made by the locals, paintings of the evangelism Epoque, industrial objects, furniture from the mansions, and a large jewelry collection of the General Antonino Taboada’s family. On the second floor of the center, there is the Ramón Gómez Cornet Museum of Fine Arts with works of local and national artists. Paintings by Carlos Alonso, Guillermo Butler, Leopoldo Presas, and Raúl Soldi are especially valuable.